Discontinue if NMS occurs; in severe neutropenia (ANC <1,000/mm
3). Consider discontinuation if signs & symptoms of tardive dyskinesia appear; at 1st sign of clinically significant decline in WBC. Consider dose reduction or stopping treatment if compulsive behaviors develop. Not for treatment of dementia-related psychosis. Cerebrovascular adverse reactions eg, stroke, transient ischemic attack; syndrome of potentially irreversible, involuntary, dyskinetic movements; hyperglycemia/DM, dyslipidemia, wt gain; pathological gambling & compulsive behaviors; orthostatic hypotension; somnolence, postural hypotension, motor & sensory instability leading to falls & fractures or other injuries; leukopenia, neutropenia, agranulocytosis; disruption of body's ability to reduce core body temp; esophageal dysmotility & aspiration. Patients w/ history of seizures or conditions that lower seizure threshold; risk for aspiration pneumonia. Monitor worsening of glucose control; symptoms of hyperglycemia; wt; fever or other symptoms or signs of infection in patients w/ clinically significant neutropenia. Perform fasting blood glucose testing in patients w/ risk factors for DM at the beginning & periodically during treatment; CBC in patients w/ history of clinically significant low WBC/ANC or drug-induced leukopenia/neutropenia during 1st few mth of therapy. May impair ability to drive or operate machinery. Pregnancy & lactation. Childn ≤18 yr. Elderly w/ dementia-related psychosis.
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